The Role of the Mammalian Target of Rapamycin (mTOR) in Pulmonary Fibrosis

The document discussed the role of the mTOR pathway in pulmonary fibrosis, highlighting its importance in cell metabolism, proliferation, differentiation, and survival. Dysregulation of mTOR signaling was linked to autophagy, inflammation, and cell growth issues, contributing to lung fibrosis. The review emphasized that mTOR inhibitors, already studied in cancer therapy, showed promise in treating fibroproliferative diseases like idiopathic pulmonary fibrosis and radiation-induced pulmonary fibrosis, making mTOR a potential therapeutic target for these conditions.