The association of Wnt – Factor TCF7L2 (TCF4) gene polymorphism and treated Alopecia Areata (Platelet rich plasma Vs conventional)

This study investigated the association between TCF7L2 gene polymorphism and alopecia areata, involving 86 subjects divided into healthy individuals and patients with alopecia areata. The patients were further split into two treatment groups: 20 received conventional therapy, and 23 were treated with Platelet Rich Plasma (PRP). The study found that the CT, TT, and CT+TT genotypes of TCF7L2 were significantly more common in alopecia areata patients compared to healthy controls. However, there was no significant difference in treatment outcomes between PRP and conventional therapy across different TCF7L2 genotypes, except for the presence of exclamation mark hairs in the PRP group. The study concludes that while TCF7L2 polymorphism is associated with alopecia areata, it does not significantly influence the effectiveness of PRP versus conventional treatment.