TGF-β Signaling: a Potential Therapeutic Target of Single Herbs and Extracts for Renal Fibrosis

The document discussed the role of transforming growth factor β (TGF-β) in the progression of renal fibrosis, a key factor in chronic kidney disease leading to end-stage kidney disease. It highlighted that several studies demonstrated the potential of individual Chinese herbal extracts to inhibit TGF-β activation and reduce extracellular matrix formation, thus exerting an anti-renal fibrosis effect. The research trends in using single traditional Chinese medicines and extracts for preventing and treating renal fibrosis were summarized, offering insights for developing new strategies to prevent and delay the condition.