TGF-β Signaling: a Potential Therapeutic Target of Single Herbs and Extracts for Renal Fibrosis

The document discussed the role of transforming growth factor β (TGF-β) in the progression of renal fibrosis, a key factor in chronic kidney disease leading to end-stage kidney disease. It highlighted that several studies demonstrated the potential of individual Chinese herbal extracts to inhibit TGF-β activation and reduce extracellular matrix formation, thus providing an anti-renal fibrosis effect. The research trends in using single traditional Chinese medicines and extracts for preventing and treating renal fibrosis were summarized, offering insights for new preventive and therapeutic strategies.