Association of Small, Dense LDL Cholesterol With Acute Myocardial Infarction in Young Population

The study investigated the association of small, dense low-density lipoprotein (sd-LDL) cholesterol levels with acute myocardial infarction (AMI) in a young population under 40 years old. It was a case-control study with 100 patients who had AMI and 50 age and sex-matched healthy controls without CAD. The results showed that patients with AMI had significantly higher levels of LDL, VLDL, triglycerides, sd-LDL, Lp(a), and homocysteine, and lower levels of Apolipoprotein A1 and HDL compared to controls. The mean sd-LDL level was significantly higher in cases (24.59 ± 15.61) than in controls (10.02 ± 1.10), and the odds ratio for sd-LDL was 1.497 (1.037-2.162), indicating a strong association. The study concluded that sd-LDL is a potential marker for predicting the risk of AMI in young adults, with higher levels observed in patients who were smokers and obese.