Skin Care Properties of Grape Seed Polyphenols, a By-Product of the Winery Industry

The document from 2012 reviews the beneficial skin care properties of grape seed polyphenols, by-products of the winery industry, highlighting their antioxidant, anti-inflammatory, antimicrobial, and anticarcinogenic effects. Studies cited include grape seed extract's promotion of hair follicle cell proliferation by 230% and conversion of hair cycles from telogen to anagen phase in mice, its potent antibacterial effects against MRSA, prevention of melasma in humans, and inhibition of skin carcinogenesis in mice. Grape seed extract also reduced UVB-induced skin tumor development, inflammation, and immunosuppression in mice by modulating inflammatory cytokines and enhancing DNA repair mechanisms, although these effects require interleukin-12. The extract was well-tolerated in rat toxicity studies, indicating safety for potential human studies. The document suggests the need for further research to understand grape seed polyphenols' pharmacological effects and to develop topical delivery systems.