Protective Effects of Selenium in Patients with Beta-Thalassemia Major

March 2020 in “ ̒Ulūm-i dārūyī ”

ajand aboutalebi, Abolghasem Jouyban, Hadi Chavoshi, Aliakbar Movassaghpour Akbari, Elnaz Shaseb, Parvin Sarbakhsh, Saba Ghaffary

selenium hair loss

Studysummary This study found that one month of selenium supplementation improved liver and kidney function biomarkers and reduced severe hair loss in patients with beta-thalassemia major. Our plain-language summary of this paper — not a Tressless recommendation.

In a clinical trial involving 34 beta-thalassemia major patients, selenium supplementation (200 µg/day for one month) significantly improved liver and kidney function markers, including ALT, AST, and serum creatinine levels. Additionally, selenium supplementation notably enhanced hair profile and reduced severe hair loss. The study concluded that selenium has protective effects on liver and kidney functions and improves hair health in beta-thalassemia major patients, though further research is needed.

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Research cited in this study

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research Diet and Hair Loss: Effects of Nutrient Deficiency and Supplement Use

79 citations , January 2017 in “Dermatology practical & conceptual”

This article addresses the need to screen for nutrient deficiencies in patients with hair loss but reports no new findings, noting that supplementation without deficiency may not be beneficial and could pose risks.

research The Impact of Oxidative Stress on Hair

59 citations , November 2015 in “International Journal of Cosmetic Science”

This review considers oxidative stress effects on hair aging and emphasizes the need for dermatologists to recognize and treat factors affecting scalp and hair health, but it provides no new clinical findings.

research Selenoproteins Are Essential for Proper Keratinocyte Function and Skin Development

101 citations , August 2010 in “PLoS ONE”

In this mouse study, severe selenoprotein deficiency in epidermal cells was linked to skin abnormalities, disrupted hair follicle development, and progressive alopecia, highlighting the role of selenoproteins in skin and hair health.

research Acute Selenium Toxicity Associated With a Dietary Supplement

382 citations , February 2010 in “Archives of Internal Medicine”

This study identified that high concentrations of selenium in a liquid dietary supplement caused a widespread outbreak of poisoning, revealing the importance of stricter manufacturing standards.

research Selenium as an Element in the Treatment of Ovarian Cancer in Women Receiving Chemotherapy

127 citations , March 2004 in “Gynecologic oncology”

This study concluded that selenium supplementation for ovarian cancer patients during chemotherapy may have several beneficial effects, such as increased antioxidant enzyme activity, reduced chemotherapy-related symptoms, and higher selenium levels in serum and hair.

research Macrocytosis and Pseudoalbinism: Manifestations of Selenium Deficiency

126 citations , November 1987 in “The Journal of Pediatrics”

This study reports that selenium deficiency in children on long-term total parenteral nutrition may lead to symptoms like erythrocyte macrocytosis and skin and hair depigmentation, which improved with selenium supplementation.