Safety Data of Four Treatment Regimens in Early Rheumatoid Arthritis Patients

    February 2016 in “ Annals of the Rheumatic Diseases ”
    E Fedorenko, GV Lukina, Ya. A. Sigidin
    TLDR All four treatments for early rheumatoid arthritis had similar and mostly mild side effects.
    The study compared the safety of four different DMARD treatment regimens in 141 early rheumatoid arthritis patients over one year. The regimens included methotrexate (MTX), MTX plus prednisolone (MTX-P), MTX-P plus methylprednisolone (MTX-P-MP), and leflunomide (LEF). Side effects were similar across groups, with 24.3%-26% of patients experiencing them. Six patients discontinued therapy due to side effects, mostly in the LEF group. The MTX-P group had no therapy withdrawals. Most side effects were moderate or minimal, with the most serious ones occurring in the LEF group.
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