Dermal Safety Comparison of 0.05% Desonide Cream and 1.0% Hydrocortisone Cream

    April 1993 in “ Current Therapeutic Research ”
    Roger C. Cornell, Michael Baker
    TLDR Both creams are equally safe, but hydrocortisone may cause more visible blood vessels.
    In a double-blind, randomized study involving 30 patients with seborrheic dermatitis of the scalp, 0.05% desonide cream and 1.0% hydrocortisone cream were compared over 8 weeks. Clinical evaluations showed no statistical differences between the two treatments in terms of atrophy or other side effects. However, there were slightly more instances of telangiectasia in the hydrocortisone-treated areas.
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