Research on the balance of thiol-disulfide in blood serum in women with telogen effluvium
January 2019
in “International Journal of Trichology”
TLDR The balance of thiol-disulfide in women with hair loss is affected but not damaged.
In 2019, three studies were conducted on the balance of thiol-disulfide in blood serum in women with telogen effluvium (TE), a common hair loss condition. The first study involved 60 women and found that the thiol-disulfide balance was significantly disrupted in women with TE, suggesting oxidative stress might play a role in the condition. The second study, involving 52 TE patients and 46 controls, found no statistical difference in native thiol, disulfide, and total thiol levels between the groups, indicating that oxidative stress may not play a significant role in TE. The third study, with an unspecified number of patients, found that cysteine, a component of vitamin B6, contributes to hair growth and that a decrease in ferritin could lead to hair loss. It also found a correlation between TE and thyroid disease, and that native and total thiols decrease in TE with age. However, it concluded that while thiol/disulfide homeostasis is affected in TE, the balance is not damaged.
View this study on journals.lww.com →
Cited in this study
research The impact of oxidative stress on hair
Oxidative stress damages hair and contributes to aging, and managing it can help maintain hair health.
research A Hospital-based Study to Determine Causes of Diffuse Hair Loss in Women
The main causes of diffuse hair loss in women are telogen effluvium and androgenetic alopecia, often related to stress and iron deficiency.
research Pathobiology of chemotherapy-induced hair loss
Chemotherapy causes hair loss by damaging hair follicles and stem cells, with more research needed for prevention and treatment.
research Telogen effluvium
Chronic Telogen Effluvium may resolve after years and is diagnosed by examining the patient's history and clinical signs, with treatment aimed at underlying causes and possibly minoxidil.
research Iron deficiency in female pattern hair loss, chronic telogen effluvium, and control groups
Iron deficiency common in women, not always linked to hair loss; more research needed.
research Oxidative Stress in Follicular Units During Hair Transplantation Surgery
Adding more glutathione to the preservation solution doesn't reduce oxidative stress in hair transplants.
research Systematic approach to hair loss in women
A systematic approach is crucial for managing hair loss in women.
research Hair Loss in Women
Effective hair loss treatment in women requires correct diagnosis and can include medications like minoxidil, antiandrogens, and treatments for underlying conditions like PCOS.
research Oxidative stress in ageing of hair
Oxidative stress contributes to hair graying and loss as we age.
research Hair cycle and hair pigmentation: dynamic interactions and changes associated with aging
As people age, their hair follicles produce less pigment, leading to gray and white hair, due to factors like reduced enzyme activity and damage to melanocyte DNA.
research Decreased Serum Ferritin is Associated With Alopecia in Women
Low iron levels may be linked to some types of hair loss in women.