Recent Developments in the Treatment of Obesity with Particular Reference to Semistarvation Ketogenic Regimens
November 1978
in “
Diabetes Care
”
TLDR The document concludes that a high-protein, low-carb diet can lead to significant weight loss but requires caution and further research.
The 1978 document reviews three experimental obesity treatments: behavior modification, semistarvation ketogenic regimens, and surgical therapy. It emphasizes the Protein-Sparing Modified Fast (PSMF), a semistarvation ketogenic regimen effective for significant weight loss, typically over 40 pounds. PSMF involves high biological value protein, potassium supplementation, and carbohydrate avoidance to maintain ketosis, but is not suitable for certain groups like pregnant women or those with severe organ disease. Case studies, including a diabetic patient weaned off insulin and a Prader-Willi syndrome patient maintaining weight loss, illustrate PSMF's potential. However, the document criticizes dangerous "liquid protein diets" and acknowledges the investigational nature of these treatments, advocating for informed consent and further research. Surgical options are considered for individuals over 200% of their desirable body weight, while behavior modification is recommended for those with less than 130% of desirable body weight.
