TLDR The skin fully recovered after using the optical clearing agent, showing no long-term harm.
The study investigated the effects of a mixture of PEG-400 and Thiazone, used as optical clearing agents (OCAs), on rat skin. It was found that while the application initially stunted hair growth and caused some abnormal thickening and vacuoles in the epidermis, as well as denser collagen arrangement, these effects were temporary. After 2 weeks, the skin's morphology and microstructure fully recovered, indicating no long-term adverse effects. This research provided a method for assessing the safety of OCAs on skin.
5 citations
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February 2022 in “Acta Biomaterialia” Nanomaterials can improve hair care products and treatments, including hair loss and alopecia, by enhancing stability and safety, and allowing controlled release of compounds, but their safety in cosmetics needs more understanding.
19 citations
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January 2020 in “Journal of Biophotonics” A PEG-400/oleic acid mixture best improves drug delivery monitoring through hair follicles.
Candlenut oil nanoemulsion increases hair growth in male rats and remains stable for 14 days at room temperature.
11 citations
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January 2006 in “Drug development and industrial pharmacy” Adding TPGS to minoxidil solutions can improve skin penetration and retention, especially in water and PEG 400-based solutions.
Polyethylene glycol 400 and glycerol are effective as moisturizers in anti-hair loss cream with saw palmetto extract.
