Preliminary Investigations of Rat Skin After Topical Application of Optical Clearing Agent

    October 2010 in “ Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE ”
    Jing Wang, Dan Zhu
    TLDR The skin fully recovered after using the optical clearing agent, showing no long-term harm.
    This study investigated the effects of a mixture of PEG-400 and Thiazone, used as an optical clearing agent (OCA), on rat skin. The research focused on overcoming the barrier of the stratum corneum and epithelium to enhance light penetration for optical diagnosis and treatment. Initial findings showed that within the first week, hair growth was stunted, and there were changes in the epidermis, such as abnormal thickening and vacuole formation, with denser collagen arrangement. However, by the second week, the skin's morphology and microstructure fully recovered, indicating no long-term adverse effects. This study provided a method for assessing the safety of OCAs on skin.
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