NCOG-40: Rare Adverse Effect of Temozolomide in a 65-Year-Old Female with Glioblastoma Multiforme: A Case Report

This case report discusses a rare adverse effect of temozolomide, an antineoplastic agent used to treat glioblastoma multiforme (GBM), in a 65-year-old woman. While common side effects include nausea, vomiting, and alopecia, the patient developed severe bone marrow suppression, leading to aplastic anemia and subsequent death. This rare complication, occurring in less than 1% of cases, highlights the need for increased awareness and potentially more frequent monitoring of blood work in patients undergoing temozolomide treatment. The report suggests that a more tailored approach to monitoring may be necessary to identify patients at risk for this life-threatening side effect.