NCOG-40: Rare Adverse Effect of Temozolomide in a 65-Year-Old Female with Glioblastoma Multiforme: A Case Report
November 2024
in “
Neuro-Oncology
”
TLDR Temozolomide can cause severe bone marrow suppression, leading to life-threatening complications.
This case report discusses a rare adverse effect of temozolomide, an antineoplastic agent used to treat glioblastoma multiforme (GBM), in a 65-year-old woman. While common side effects include nausea and alopecia, the patient developed severe bone marrow suppression, leading to aplastic anemia and her subsequent death. This highlights the importance of increased awareness and potentially more frequent monitoring of blood work in patients receiving temozolomide, as current protocols vary and may not adequately prevent this life-threatening complication.