Pruritic Rash with Actinic Keratosis and Impending Exfoliation in a Patient with Hypertension Managed with Minoxidil

    September 1988 in “ Drug intelligence & clinical pharmacy ”
    Bruce H. Ackerman, Michael E. Townsend, William E. Golden, Ann B. Bryan
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    TLDR Minoxidil caused a severe rash in a patient, which improved after stopping the drug.
    A 54-year-old male with hypertension treated with minoxidil for three years developed a pruritic, erythematous rash that progressed to multiple body areas and impending exfoliation. The rash improved after minoxidil was withdrawn and treated with topical corticosteroids, but reappeared upon accidental rechallenge with the drug. This case highlighted a rare instance of late-onset dermatological toxicity from chronic minoxidil use, suggesting the rash was drug-induced rather than due to other conditions.
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