PRP Application in the Treatment of Knee Osteoarthritis: A Comprehensive New Perspective in Light of Current Literature and Clinical Consensus Reports

This review discusses the use of platelet-rich plasma (PRP) as a treatment for knee osteoarthritis, highlighting its potential benefits in inflammation modulation, cartilage regeneration, and symptom relief. PRP's therapeutic effects are linked to its bioactive components, such as growth factors and cytokines, which aid in tissue healing and inflammation regulation. Clinical studies show PRP's efficacy in reducing pain and improving function, particularly in mild-to-moderate cases. However, outcomes vary due to differences in preparation protocols, dosage, and patient characteristics, emphasizing the need for standardized protocols. Despite its promise, further high-quality, long-term studies are necessary to optimize PRP treatment protocols.