Proliferation, But Not Apoptosis, Is Associated With Distinct Beta-Catenin Expression Patterns in Non-Small-Cell Lung Carcinomas
November 2002
in “
The American journal of pathology
”
TLDR Distinct β-catenin patterns are linked to cell growth, not cell death, in lung cancer.
The study investigated β-catenin expression patterns in 92 non-small-cell lung carcinomas (NSCLCs) and their association with cell proliferation and apoptosis. It found that distinct β-catenin expression patterns were linked to cell proliferation but not to apoptosis. The research highlighted the complex role of β-catenin in cancer, noting that its membranous localization was often associated with cell adhesion and better differentiation, while nuclear and cytoplasmic presence correlated with mutations and increased proliferation. The findings underscored the importance of β-catenin in tumor behavior and its potential as a prognostic marker.
