Proliferating trichilemmal cyst with histological malignant transformation: Identification of hair sheath keratins in the tumor.
January 1989
in “
The Nishinihon Journal of Dermatology
”
TLDR A hair cyst can become cancerous, showing specific keratins from the hair sheath.
The document reported a case of a proliferating trichilemmal cyst with histological malignant transformation and reviewed 13 cases of malignant trichilemmal cysts with metastasis from the literature. In the malignant transition area of a typical proliferating trichilemmal cyst, spindle-shaped cells proliferating in a herring-bone pattern were observed. Keratins were extracted from the tumor and identified using two-dimensional gel electrophoresis, revealing keratins of 56Kd (PI 7.8), 48Kd (PI 5.1), and 46Kd (PI 5.1), which are specific to the outer root sheath. Epidermal keratins were not detected.
