Mon-317 Prognostic Factors and Mortality According to the Structural and Functional Classification of Acromegaly

The study investigated prognostic factors and mortality in acromegaly patients based on the structural and functional classification of somatotroph adenomas. It involved 222 patients, with a mean age of 40 years, classified into three types: type 1 (dense granulated microadenomas), type 2 (intermediate), and type 3 (sparsely granulated, highly invasive macroadenomas). Type 3 patients exhibited the worst prognosis, with higher disease activity, comorbidities, and mortality risk compared to types 1 and 2. The study highlighted that type 3 acromegaly was associated with increased hypertension, cardiovascular disease, diabetes, hypertriglyceridemia, and high LDL-c levels. Multivariate analysis confirmed type 3's poor prognosis, emphasizing the need for tailored treatment strategies.