Pretibial Myxedema with Graves' Disease: A Case Report and Review of Japanese Literature

    April 1998 in “ The Journal of Dermatology ”
    Toshiyuki Ishizawa, Hiroshi Sugiki, Shin‐ichi Anzai, Shigeo Kondô
    TLDR Pretibial myxedema can occur with Graves' disease, showing skin changes like waxy plaques and swelling.
    This document reported a case of pretibial myxedema in an 18-year-old Japanese woman with Graves' disease, characterized by waxy indurated plaques and nonpitting edema on her lower legs. Histological examination showed a thickened dermis with abundant mucin, particularly hyaluronic acid, and collagen fibers splitting into fibrils. Additionally, the document reviewed 112 cases of pretibial myxedema from Japanese literature, providing a broader context for understanding this condition in relation to Graves' disease.
    Discuss this study in the Community →