Pretibial Myxedema with Graves' Disease: A Case Report and Review of Japanese Literature

The document reported a case of pretibial myxedema associated with Graves' disease in an 18-year-old Japanese woman, characterized by waxy indurated plaques and nonpitting edema on her lower legs. Histological examination showed a thickened dermis with abundant mucin, particularly hyaluronic acid, and collagen fibers splitting into fibrils. Additionally, the authors reviewed 112 cases of pretibial myxedema from Japanese literature to provide a broader context for this condition.