Preparation and Evaluation of Topical Formulation of Diphenylcyclopropenone for the Treatment of Alopecia Areata

    June 2023 in “ International Journal of Clinical Research and Reports ”
    Atefeh Naeimifar, Behnaz Daneshmand, Negar Namini, Fatemeh Amiri, Alur S. Kumar, Saman Ahmad Nasrollahi
    TLDR Method B with propylene glycol is better for stable low-concentration DPCP solutions for alopecia areata.
    The study evaluated the stability of diphenylcyclopropenone (DPCP) in topical solutions for treating alopecia areata, using two preparation methods. Method A used acetone, while Method B used propylene glycol diluted with acetone. Over 6 months at 5ºC±3ºC, high concentrations (2%, 1%, 0.5%) of DPCP remained stable, whereas lower concentrations (0.05%, 0.1%, 0.01%) showed decreased stability after 3 months. Method B, using propylene glycol, is recommended for lower concentrations due to better stability. These findings aid in developing effective DPCP solutions for alopecia areata treatment.
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