Phase III Randomized Clinical Trial Comparing Primary Surgery Versus Neoadjuvant Chemotherapy in Advanced Epithelial Ovarian Cancer With High Tumor Load (SCORPION Trial): Final Analysis of Peri-Operative Outcome

    March 2016 in “ European journal of cancer ”
    Anna Fagotti, Gabriella Ferrandina, Giuseppe Vizzielli, Francesco Fanfani, Valerio Gallotta, Vito Chiàntera, Barbara Costantini, Pasquale Alessandro Margariti, Salvatore Gueli Alletti, Francesco Cosentino, Lucia Tortorella
    TLDR Neoadjuvant chemotherapy followed by surgery leads to fewer severe complications and better quality of life than immediate surgery in advanced ovarian cancer patients with high tumor load.
    The SCORPION trial compared primary debulking surgery (PDS) to neoadjuvant chemotherapy (NACT) followed by interval debulking surgery (IDS) in 110 women with advanced epithelial ovarian cancer and high tumor load. The NACT/IDS group had significantly fewer severe perioperative complications (5.7% vs. 52.7%) and better quality of life scores than the PDS group. The study concluded that NACT/IDS was associated with lower morbidity and better quality of life, suggesting careful assessment of PDS in these patients, with further analysis needed for overall survival efficacy.
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