Nuclear And Cytosol Androgen Receptor In Androgen-Dependent Dermatoses In Female Patients

    July 2009 in “ Experimental and Clinical Endocrinology & Diabetes ”
    Jolanta B. Schmidt
    TLDR Nuclear AR levels give better insight into hormone effects in skin conditions.
    The study investigated androgen receptor (AR) levels in 34 female patients with androgen-dependent dermatoses, including acne, hirsutism, and androgenetic alopecia. Biopsies were taken on day 21 of the menstrual cycle, and AR levels were assessed in both cytosol and nuclear fractions. The results showed that 76% of cases were positive for AR, with 86% of androgenetic alopecia, 80% of acne, and 60% of hirsutism patients showing positive results. While cytosol AR levels did not differ significantly among the conditions, nuclear AR levels were highest in hirsutism, followed by androgenetic alopecia and acne. The study concluded that nuclear AR assays provide a more comprehensive understanding of local hormone action compared to cytosol AR assays alone.
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