New Synthesis of Methyl 3β-Hydroxy-5-androstene-17β-carboxylate
January 2002
in “
Chinese Journal of Pharmaceuticals
”
TLDR A new method was developed to make a compound used in finasteride and epristeride with a 69% yield.
The document detailed a synthesis process for methyl 3β-hydroxy-5-androstene-17β-carboxylate, an important intermediate in the production of finasteride and epristeride. This compound was synthesized from pregnenolone acetate through a bromoform reaction followed by esterification, achieving an overall yield of 69%.