Neuropeptides in the Skin

The document reviewed the role of neuropeptides in skin physiology and pathology, focusing on their effects on skin processes and interactions with skin cells and immune components. Neuropeptides such as Substance P (SP) and Calcitonin Gene-Related Peptide (CGRP) were involved in inflammatory responses and conditions like psoriasis, atopic dermatitis, leprosy, and alopecia. SP was noted for its pro-inflammatory effects, while CGRP had both pro-inflammatory and anti-inflammatory properties. The study highlighted the importance of cutaneous nerve fibers in skin homeostasis and neurogenic inflammation. Neuropeptides played crucial roles in skin repair and immune responses, with potential therapeutic applications, although the neural component in skin disease pathogenesis was not fully understood. In alopecia, neuropeptides like SP were implicated in hair growth regulation, but their role in hair follicle homeostasis was inconclusive.