Mycophenolate Mofetil in Patients with Autoimmune Hepatitis Intolerant to Azathioprine

    September 2010 in “ Gut ”
    Dinesh Jothimani, U. Warshow, U. Warshow, M. Cramp, M. Cramp, Tim Cross, Troy J. Cross
    TLDR Mycophenolate mofetil is a good alternative for autoimmune hepatitis patients who can't tolerate azathioprine.
    This study evaluated the efficacy and tolerability of mycophenolate mofetil (MMF) in 20 patients with autoimmune hepatitis (AIH) who were intolerant to azathioprine. The retrospective review spanned from 2000 to 2010 and included 117 AIH patients, with 17% receiving MMF. Patients were initially treated with prednisolone and azathioprine, but azathioprine was discontinued due to adverse effects in 18 patients. MMF was administered at a median dose of 1 g twice daily alongside low-dose prednisolone. Over a median follow-up of 47 months, MMF was well tolerated, with 14 out of 19 patients remaining in remission, including those with cirrhosis. Intolerance to MMF was noted in three patients, and two showed poor response. The study concluded that MMF was a viable second-line treatment for AIH patients intolerant to azathioprine.
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