The Multisystem Impact of Long COVID: A Comprehensive Review

    January 2024
    Nicoleta Negruț, Menegas Georgios, Sofia Kampioti, Maria Bourelou, Francesca Kopanyi, Fazilah Hassan, Anamaria Asowed, Fatima Zohra Taleouine, Anca Ferician, Paula Marian
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    Studysummary This study systematically reviewed recent literature to demonstrate that Long COVID involves complex, multi-systemic symptoms, influenced by factors such as pre-existing conditions and vaccination status, complicating its diagnosis and treatment. Our plain-language summary of this paper — not a Tressless recommendation.
    The review comprehensively examines the multisystem impact of Long COVID, highlighting its complex and persistent nature across various bodily systems such as pulmonary, cardiovascular, gastrointestinal, neuropsychiatric, dermatological, renal, hematological, and endocrinological. It identifies factors like pre-existing conditions, initial COVID-19 severity, vaccination status, gender, and age as influential in the manifestation and persistence of symptoms. The findings emphasize the need for a nuanced understanding of Long COVID's diverse manifestations to effectively manage and address this evolving condition over time.
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