Minoxidil and Its Use in Hair Disorders: A Review

    Poonkiat Suchonwanit, Thammarucha S, Kanchana Leerunyakul
    From the encyclopedia
    Minoxidil →

    An essential vasodilator with some anti-androgenic effects

    Spironolactone →

    powerful topical and oral anti-androgen used mostly by women

    Studysummary In this study, a combination of low-dose minoxidil 0.25 mg and spironolactone 25 mg reduced hair shedding and improved hair density in patients with female pattern hair loss, with mild adverse effects.
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    The corrigendum addressed errors in a previous publication regarding the use of minoxidil and spironolactone for female pattern hair loss (FPHL). The correct dosage of minoxidil was 0.25 mg, not 2.5 mg, when combined with spironolactone 25 mg. This combination showed favorable outcomes, including reduced hair shedding and improved hair density, with a mean reduction in hair shedding score of 2.3 at 6 months and 2.6 at 12 months. Mild adverse effects such as urticaria, postural hypotension, and facial hypertrichosis were reported. The authors acknowledged the errors and clarified that the reduction in severity score pertained to the visual-analogue Sinclair hair shedding scale.
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