Mimosine Dipeptide Enantiomsers: Improved Inhibitors against Melanogenesis and Cyclooxygenase

The study investigated mimosine dipeptides as inhibitors of melanogenesis and cyclooxygenase (COX) enzymes. Mimosine dipeptides, particularly Mi-d-Val, were more effective than mimosine in inhibiting tyrosinase, reducing melanin content, and intracellular tyrosinase activity in B16F10 melanoma cells. They also inhibited COX enzymes, with some dipeptides surpassing the anti-inflammatory drug indomethacin in potency. The research suggested that mimosine dipeptides could be promising for treating hyperpigmentation and inflammation-related disorders, as they effectively inhibited melanogenesis and COX-1/2 with minimal impact on cell growth or viability.