Micturitional Disturbance in a Patient with Adrenomyeloneuropathy

    January 1998 in “ Neurourology and Urodynamics ”
    Ryuji Sakakibara, Takamichi Hattori, Toshio Fukutake, Masahiro Mori, Tomonori Yamanishi, Kosaku Yasuda
    TLDR AMN can cause bladder problems due to nerve damage.
    The document reported a case of adrenomyeloneuropathy (AMN) in which a patient experienced neurogenic bladder dysfunction, beginning with hair loss at age 12 and progressing to urinary urgency, difficulty voiding, fecal incontinence, erectile impotence, and gait disturbance by age 25. By age 31, the patient exhibited diffuse baldness, spastic paraparesis, and disturbed vibratory sensation, with diagnostic tests confirming AMN. Initial urodynamic studies showed impaired bladder function, which worsened by age 38, as the patient became apathetic and demented, requiring diapers. MRI revealed high signal intensities in cerebral white matter, and further urodynamic studies indicated increased residual urine volume and decreased bladder capacity. The study suggested that demyelinating lesions in the peripheral nerve and white matter of the spinal cord and cerebrum were primarily responsible for the micturitional disturbances observed in the patient.
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