Metformin as an adjunct therapy for the treatment of moderate to severe acne vulgaris

The literature review conducted six years ago evaluated the use of metformin as an additional treatment for moderate-to-severe acne vulgaris in individuals not diagnosed with polycystic ovary syndrome (PCOS) or androgen excess. The authors found three clinical trials and randomized controlled trials that met their criteria. These studies excluded participants diagnosed with PCOS or androgen excess. The results from all three studies indicated that metformin was an effective additional therapy in the treatment of moderate-to-severe acne vulgaris.