Metabolism of Subtoxic Levels of Selenium in Animals and Humans

    December 1996 in “ PubMed ”
    P.D. Whanger, S.C. Vendeland, Y.-C. Park, Yiming Xia
    TLDR The safe daily selenium intake is up to 819 micrograms.
    The study reviewed the metabolism of subtoxic levels of selenium in animals and humans, focusing on absorption and transport mechanisms. It found that the intestinal tract had a high tolerance for selenium, with selenomethionine (SeMet) being absorbed more efficiently than selenate and selenite. Selenite was metabolized extensively during absorption, while SeMet and selenate appeared largely unchanged in the vascular effluent. In a high selenium area in China, selenium toxicity symptoms included cracked fingernails and hair loss. The low adverse effect level (LOAEL) for dietary selenium was about 1540 ± 653 micrograms per day, and the maximum safe level (NOAEL) was 819 ± 126 micrograms per day.
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