Mechanisms regulating skin immunity and inflammation

The document from April 11, 2014, reviews the complex regulatory networks that control skin immunity and inflammation, with a focus on the interactions between host and microbial cellular components of the skin. It discusses the roles of various immune cells, including dendritic cell subsets, plasmacytoid DCs, macrophages, and monocytes, in skin diseases like psoriasis and atopic dermatitis. The review also examines the importance of keratinocytes in initiating inflammation and the potential of innate lymphoid cells as biomarkers and therapeutic targets in psoriasis. Additionally, it explores the dual role of skin microbiota in both defending against infection and contributing to inflammatory skin diseases. The document underscores the need for further research to fully understand the mechanisms of immune regulation in the skin and to translate findings from mouse models to human skin.