Mast cell deficient and neurokinin-1 receptor knockout mice are protected from stress-induced hair growth inhibition
March 2005
in “Journal of Molecular Medicine”
TLDR Certain mice without specific receptors or mast cells don't lose hair from stress.
The study demonstrated that both neurokinin-1 receptor knockout mice (NK-1R) and mast cell-deficient mice (W/W) did not experience stress-induced premature catagen phase or hair follicle apoptosis, unlike wild-type mice. This suggests that the interaction between substance P (SP) and mast cell activation through NK-1R is key in regulating hair follicle response to stress. The absence of stress-induced upregulation of SP positive nerve fibers in NK-1R and W/W mice further supports this pathway's role in hair growth regulation. The findings indicate that targeting the SP and NK-1R pathway could be a potential strategy for preventing stress-induced hair loss. Specific numbers of mice and hair follicles analyzed were not mentioned in the summary, but the document indicated a thorough examination across different mice and hair follicles.
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