Lysophosphatidic acid increases the proliferation and migration of adipose-derived stem cells via the generation of reactive oxygen species

The study demonstrated that lysophosphatidic acid (LPA) increased the proliferation and migration of adipose-derived stem cells (ASCs) through the generation of reactive oxygen species (ROS) and activation of specific signaling pathways. The LPA1 receptor was crucial for these effects, as its inhibition significantly reduced them. LPA treatment also upregulated miR-210 and Serpine1, with Serpine1 playing a role in ASC migration. These findings suggested that LPA could be used to stimulate ASCs during stem cell expansion, indicating its potential application in enhancing stem cell growth and migration.