Low sex hormone-binding globulin is associated with low high-density lipoprotein cholesterol and metabolic syndrome in women with PCOS
June 2006
in “Human Reproduction”
TLDR Women with PCOS who have low SHBG are more likely to have low good cholesterol and metabolic syndrome.
In a study of 106 young Taiwanese women with polycystic ovary syndrome (PCOS), researchers found that low sex hormone-binding globulin (SHBG) levels were associated with low high-density lipoprotein cholesterol (HDL-C) levels and the presence of metabolic syndrome, independent of insulin resistance and obesity. The average age of the participants was 24.9 years, and 65.1% had HDL-C levels below 50 mg/dl. The study showed a strong correlation between SHBG and HDL-C levels and found that women with PCOS and metabolic syndrome had significantly lower SHBG levels, suggesting that SHBG may be an important factor in assessing cardiovascular disease risk in this population.
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Cited in this study
research Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome
The 2003 consensus updated PCOS diagnosis criteria and highlighted increased risks of diabetes and heart disease for those affected.