Low-Dose Oral Minoxidil for Frontal Fibrosing Alopecia: A 122-Patient Case Series

    February 2025 in “ Actas Dermo-Sifiliográficas ”
    C. Pindado-Ortega, Rodrigo Pirmez, DanielFernandes Melo, L. Junqueira Fortes Binato, M.L. Porriño-Bustamante, J. Barreto Carpi, Rocío Gil‐Redondo, Ángela Hermosa‐Gelbard, Juan ­Jimenez‐Cauhe, David Saceda‐Corralo, Sergio Vañó‐Galván
    TLDR Low-dose oral minoxidil can help improve hair and eyebrow growth in people with frontal fibrosing alopecia.
    The study analyzed the effectiveness of low-dose oral minoxidil in treating frontal fibrosing alopecia (FFA) in a case series of 122 patients across centers in Brazil and Spain. Results showed that 45.1% of patients experienced improvement in the density of the frontotemporal hairline, with 34.4% showing mild, 9.0% moderate, and 1.6% excellent improvement. Additionally, 57.4% of patients saw improved hair density in the interparietal area, 25.4% experienced eyebrow growth, and 3.3% had eyelash growth. Adverse effects were reported in 33.6% of patients, with hypertrichosis being the most common at 23.8%. The study suggests that oral minoxidil can be an effective complementary therapy for FFA, enhancing hair and eyebrow growth and frontotemporal hairline density.
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