The Effect of Long-Chain Monoenes on Prostaglandin E2 Synthesis by Rat Skin
July 1977
in “
Lipids
”
TLDR High levels of certain fats in rapeseed oil can reduce the skin's ability to produce prostaglandin E2 and cause hair loss and skin issues in rats.
The study investigated the impact of long-chain monoenes on prostaglandin E2 (PGE2) synthesis in rat skin, particularly focusing on the effects of rapeseed oils. Male Sprague-Dawley rats were fed various diets, including those with high erucic acid rapeseed oils, for 8 weeks. It was found that the level of 18:2n−6 in the diet significantly correlated with endogenous PGE2 levels and the skin's capacity to synthesize PGE2, while no such relationship was observed with erucic acid levels. Rats fed rapeseed oil showed high endogenous PGE2 levels but had a lower capacity for PGE2 synthesis, especially those fed Zephyr rapeseed oil, which also resulted in severe hair loss and dermal lesions. A significant negative correlation was noted between dietary monoenes, particularly oleic acid (18:1n−9), and PGE2 synthesis capacity, suggesting an inhibitory effect on the prostaglandin synthesizing enzyme system.
