Life Sciences Discovery And Technology Highlights

    April 2019 in “ SLAS TECHNOLOGY ”
    David Yeo, Tal Murthy
    TLDR New technologies show promise in healing wounds, treating cancer, autoimmune diseases, and genetic disorders.
    The document discussed advancements in wound healing technologies, focusing on reducing reactive oxygen species (ROS) and promoting regeneration. Key innovations included ceria nanocrystals on mesoporous silica nanoparticles (MSNs) to enhance healing in rat models, cellular reprogramming to generate keratinocyte-like cells for large wounds in mice, and curcumin-incorporated gelatin nanofibers for topical applications in rats. Additionally, advancements in cancer therapy and autoimmune disease treatment were highlighted, such as DNA nanocarriers, PEGylated PLGA nanoparticles, and PTEN mRNA-loaded polymer-lipid hybrid NPs for cancer, and neutrophil-like NPs for rheumatoid arthritis. The document also covered cell membrane-coated nanoparticles for rheumatoid arthritis and CRISPR-Gold for gene editing in Duchenne muscular dystrophy (DMD) mouse models, emphasizing the potential of these technologies for treating genetic diseases.
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