Lack of Classic Histology Should Not Prevent Diagnosis of Necrolytic Acral Erythema

    November 2008 in “ Journal of the American Academy of Dermatology ”
    Danette D. Bentley, Aleodor A. Andea, Aton M. Holzer, Boni E. Elewski
    TLDR Consider necrolytic acral erythema in similar cases and treat with oral zinc sulfate.
    The document emphasized that necrolytic acral erythema (NAE) could be diagnosed based on clinical presentation and response to treatment, even in the absence of classic histological features. It highlighted a case of a 46-year-old male with hepatitis C who showed significant improvement in skin lesions after zinc sulfate treatment, supporting the NAE diagnosis despite lacking traditional histological markers. The paper underscored the importance of recognizing NAE for timely and accurate treatment, noting its frequent association with hepatitis C and the effectiveness of zinc supplementation.
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