Immunohistochemical and Biochemical Studies on the Expression of Epithelial Keratins in Clinically Unchanged Horse Skin and Foot Skin of Heavy Draft Horses with Verrucous Pastern Dermatitis Syndrome

January 2007

Renate Frase

epithelial keratins K6 K16 epidermal hyperplasia wound healing inflammatory skin diseases growth factors cytokines

TLDR Diseased horse foot skin shows increased keratin expression, similar to wound healing in mammals.

The study investigated the expression of epithelial keratins in horse skin, particularly in heavy draft horses with verrucous pastern dermatitis syndrome. Using nine antibodies against human keratins, researchers examined their cross-reactivity with equine keratins through immunohistochemistry and western blotting. The study found that antibodies against human K6 and K16 specifically cross-reacted with equine keratins, and diseased foot skin showed significantly increased expression of these keratins, correlating with epidermal hyperplasia. This pattern is similar to wound healing and inflammatory skin diseases in mammals, suggesting a conserved keratin expression response to growth factors and cytokines.

View this study on bvbr.bib-bvb.de →

Discuss this study in the Community →

Related Community Posts Join

6 / 32 results

community Results of Procyanidin B2 in clinical studies

in Treatment 13 upvotes 5 years ago

Procyanidin B2, a compound derived from Annurca apples, as a potential treatment for pattern hair loss. Several clinical studies were mentioned, which found that procyanidin B2 could increase hair growth, density, and keratin content. Other treatments such as Minoxidil, Finasteride, and RU58841 were not discussed.

community Molecular mechanisms triggered by Micronedlling -- Intersting Publication to better understand Dermarolling

26 upvotes 7 years ago

This post and conversation are about the molecular mechanisms triggered by microneedling, specifically its effects on inflammation, tissue remodeling, epithelial proliferation, differentiation, and collagen synthesis. The discussion highlights the potential benefits of microneedling for hair loss treatment.

community abusing caffeine boosts DHT levels!

in Research/Science 1 upvotes 1 year ago

Caffeine intake may increase DHT levels, but its impact on hair loss is minimal compared to genetic factors. Excessive caffeine can cause health issues, and its effects on hair loss are not directly applicable to humans based on rat studies.

community Minoxidil Response Bottlenecks: Why Sulfation and Transport Matter (And Where Tretinoin Fits In)

in Research 461 upvotes 6 months ago

Minoxidil's effectiveness is limited by the need for sulfation and proper transport to hair follicles, with tretinoin potentially enhancing its effects by promoting enzyme activity and keratinocyte differentiation. Tretinoin may improve minoxidil's response by boosting the expression of necessary enzymes and transporters.

community Fresh off the press: Dutasteride may cause chronic infertility

in Research/Science 643 upvotes 8 months ago

Dutasteride may cause chronic infertility by reducing semen volume and motility, with concerns about irreversible prostate fibrosis. Users consider switching to finasteride or using treatments like minoxidil and microneedling, weighing hair preservation against fertility.

community Are these supplements good enough or am I missing something?

in Product 1 year ago

The conversation discusses the effectiveness of various supplements for hair loss, with some users suggesting higher doses of Zinc and Vitamin C, while others recommend additional supplements like Saw Palmetto and Omega-3. It is concluded that multi-vitamins are often ineffective unless there is a deficiency, and excessive intake can harm hair follicles.