Hypersensitivity to Intravenous Ondansetron: A Case Report
August 2008
in “
Journal of Medical Case Reports
”
TLDR Ondansetron can cause serious allergic reactions, so use it carefully.
This case report described a hypersensitivity reaction in a 19-year-old woman following a single intravenous dose of ondansetron, a 5-hydroxytryptamine 3 receptor antagonist used for nausea and vomiting. The patient developed urticaria immediately after administration, which was treated successfully with dexamethasone and chlorpheniramine maleate. The reaction was deemed "probable" on the Naranjo's causality assessment scale. The report highlighted the potential for life-threatening adverse reactions with ondansetron, especially when used off-label, and emphasized the need for cautious use and awareness of unusual side effects, particularly in outpatient settings.
