Great Expectations: Induced Pluripotent Stem Cell Technologies in Neurodevelopmental Impairments

The document discussed the transformation of somatic cells into induced pluripotent stem cells (iPSCs) as a significant advancement in stem-cell research, particularly for neurodevelopmental disorders like GDD/ID, epilepsy, ASD, and ADHD. iPSCs, which are similar to embryonic stem cells but without the ethical and immune rejection issues, were used to model these disorders by reprogramming cells with disease-causing mutations. This approach provided valuable samples for studying the mechanisms and pathogenesis of these conditions, aiding in drug development and treatment planning. The article highlighted the development of iPSCs, disease models, and artificial organoids, emphasizing their potential to enhance understanding and treatment of neurodevelopmental impairments.