Effect of Iodine-Deficient Diets and Goitrogenic Substances on the Weight Growth of Wistar Rats

    August 2022 in “ International journal of biological and chemical sciences ”
    E. H. Traoré, P. A. M. Gaye, A. Bathily, F. Sow, E. Y. Thior, A. R. Diarra, J. B. Rognoni, E. Bassène
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    TLDR Iodine-deficient diets and antithyroid substances affected rat growth and behavior, but most adapted with positive weight gain.
    The study investigated the effects of iodine-deficient and iodine-rich diets, as well as diets containing antithyroid substances, on the growth and behavior of 56 male Wistar rats over a period of 120 days. The rats were divided into 14 groups of 4, with various diets including simple iodine deficiency, iodine deficiency combined with undernutrition or thiocyanate, a diet containing Propylthiouracil (PTU), and others with cassava, millet, or supplemented with selenium. Results showed that, except for groups E (iodine deficiency + thiocyanate + undernutrition) and F (PTU), the rats generally adapted to their diets and exhibited positive weight growth. Some lethargy was observed in groups B, C, D, and E around the two-month mark, which resolved after one to two weeks. Alopecia was noted in some animals from groups B, C, D, E, F, and I after three weeks, but this also resolved after one month. The mortality rate was low at 2.5%, indicating good overall experimental conditions. Significant differences were observed in average daily gain (ADG) and feed intake levels among the groups.
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