INVESTIGATION OF THE INFLUENCE OF INJECTION PULSE DURATION ON THE CAPTURE OF ELECTRONS IN A BETATRON

    May 1966 in “ Zhurnal Tekhnicheskoi Fiziki (U.S.S.R.) For English translation see Sov. Phys. - Tech. Phys. (Engl. Transl.) ”
    N.I. Tulinova
    The study investigated the role of progesterone and its metabolite 5α-dihydroprogesterone (5αP) in breast cancer using an in vivo mouse model. It was found that the growth of mammary tumors in BALB/c mice treated with progesterone was due to the conversion of progesterone to 5αP by 5α-reductase. The study demonstrated that 5αP acts as a cancer-promoter hormone, and the use of a 5α-reductase inhibitor, finasteride, blocked the tumorigenic effects of progesterone. This provided the first in vivo evidence that progesterone-induced breast tumorigenesis is mediated by 5αP, highlighting the potential of finasteride in preventing breast cancer progression.
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