Intensive Immunosuppression in Patients With Disseminated Sclerosis: Clinical Response

    July 1975 in “ PubMed ”
    E M Lance, Michael Kremer, Jasmine Abbosh, Valerie E. Jones, S C Knight, P. B. Medawar
    TLDR Intensive immunosuppression can reduce relapse rates in multiple sclerosis patients, despite some side effects.
    The study investigated the effects of intensive immunosuppression on 14 patients with multiple sclerosis (MS), using a combination of corticosteroids, Imuran (azathioprine), and antilymphocyte globulin (ALG). Patients, aged 19-58, showed varied improvement, particularly in the first few weeks of treatment. The study found a significant reduction in relapse rates compared to pre-treatment levels, although some patients experienced relapses after reducing medication. Side effects included hair loss, moon facies, weight gain, and dyspepsia, but the treatment was generally well-tolerated. The results suggested that intensive immunosuppression was a feasible and clinically acceptable approach for MS, warranting further investigation.
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