Influencia del tratamiento con alfa bloqueantes e inhibidores de la 5 alfa reductasa en los hallazgos morfológicos e inmunohistoquímicos de la hiperplasia benigna de próstata

This study examined the effects of alpha-blockers and 5-alpha reductase inhibitors on benign prostatic hyperplasia (BPH) by analyzing morphological and immunohistochemical changes in the prostate. The research involved a sample of male subjects from Campo de Gibraltar, divided into four groups: a control group, BPH patients treated with alpha-blockers, those treated with 5-alpha reductase inhibitors, and patients who underwent surgery without prior medical treatment. Key findings included an average patient age of 68 years and a mean PSA value of 2.6 ng/dL. The stroma-epithelium ratio varied across groups, with the highest ratio observed in the untreated surgical group. Notably, the glandular epithelium in prostates treated with finasteride resembled the pattern of healthy prostates, suggesting its effectiveness in mimicking normal prostate morphology.