Investigation of the Influence of Injection Pulse Duration on the Capture of Electrons in a Betatron
TLDR Finasteride can prevent breast cancer progression by blocking progesterone's conversion to a cancer-promoting hormone.
The study investigated the role of progesterone and its metabolite 5α-dihydroprogesterone (5αP) in breast cancer using an in vivo mouse model. It was found that the growth of mammary tumors in BALB/c mice treated with progesterone was due to the conversion of progesterone to 5αP by 5α-reductase. The study demonstrated that 5αP acts as a cancer-promoter hormone, and the use of a 5α-reductase inhibitor, finasteride, blocked the tumorigenic effects of progesterone. This provided the first in vivo evidence that progesterone-induced breast tumorigenesis is mediated by 5αP, highlighting the potential of finasteride in preventing breast cancer progression.