Inducible Cutaneous Inflammation Reveals a Protumorigenic Role for Keratinocyte CXCR2 in Skin Carcinogenesis

December 2008 in “ Cancer Research ”

Christophe Cataisson, Rebecca Ohman, Gopal Patel, Andrea Pearson, Margaret Tsien, Steve Jay, Lisa Nolan Wright, Henry Hennings, Stuart H. Yuspa

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research Isolation and Short-Term Culture of Primary Keratinocytes, Hair Follicle Populations, and Dermal Cells from Newborn Mice and Keratinocytes from Adult Mice for In Vitro Analysis and Grafting to Immunodeficient Mice

427 citations , April 2008 in “Nature Protocols”

research Activation of Cutaneous Protein Kinase Cα Induces Keratinocyte Apoptosis and Intraepidermal Inflammation by Independent Signaling Pathways

74 citations , September 2003 in “The Journal of Immunology”

Activating PKCα in skin causes cell death and inflammation through different pathways.

research Overexpression of Protein Kinase C-α in the Epidermis of Transgenic Mice Results in Striking Alterations in Phorbol Ester-Induced Inflammation and COX-2, MIP-2, and TNF-α Expression but Not Tumor Promotion

135 citations , October 1999 in “Journal of Cell Science”

Overexpressing PKCα in mice skin increases inflammation but doesn't affect tumor growth.