Indonesian Plants Potentially Used as Hair Growth Promoting Agents

A serum containing Centella asiatica extracellular vesicles, IGF-1, FGF-7, and caffeine significantly improved hair thickness, density, length, and reduced hair loss after 56 days. The conversation also discusses how treatments like finasteride, minoxidil, and ketoconazole address different aspects of hair loss by reducing DHT, improving blood flow, and lowering inflammation.

A new drug targeting prolactin is being discussed for hair regrowth, but skepticism remains as many still rely on minoxidil and finasteride. Concerns include the drug's effectiveness compared to existing treatments and whether it works for those already using 5AR inhibitors.

Effective hair growth treatments include finasteride, minoxidil, dutasteride, and hair transplants, with additional options like microneedling, low-level laser therapy, and PRP showing some benefits. Newer treatments such as GHK-Cu peptides and ketoconazole shampoo are promising, while others like saw palmetto and biotin are less effective unless deficiencies exist.

Hair loss may be linked to DHT, which can both suppress and increase inflammation, potentially as a defense mechanism. Treatments like Minoxidil, Finasteride, and RU58841 are discussed, but the exact cause of hair loss remains unclear.

The conversation discusses GT20029, a drug in Phase II trials that targets androgen receptors with minimal systemic effects, and TDM-105795, a growth stimulant with a different mechanism than minoxidil that may revive papilla stem cells. Both are potential new treatments for hair loss.

Minoxidil, finasteride, and RU58841 promote hair growth by different mechanisms, with minoxidil and prostaglandin E1 being specifically mentioned. Corticosteroids can also cause hair growth.