Investigation of In Vitro and In Silico Anti-Inflammatory Potential of Carthamus Caeruleus L. Root Juice

    June 2025 in “ International Journal of Molecular Sciences ”
    Idir Moualek, Hamdi Bendif, Ali Dekir, Karima Benarab, Yousra Belounis, Walid Elfalleh, Karim Houalı, Gregorio Peron
    TLDR Carthamus caeruleus root juice may reduce inflammation.
    The study explores the anti-inflammatory potential of Carthamus caeruleus L. root juice (CRJ) using in vitro and in silico methods. CRJ demonstrated significant protective effects against various stress-induced damages in erythrocytes, with protection levels up to 90.51%. It also inhibited albumin denaturation by 61.5%. Molecular docking revealed strong interactions between CRJ flavonoids and the COX-2 enzyme, suggesting a mechanism similar to standard anti-inflammatory drugs. Despite promising results, further in vivo studies are necessary to confirm CRJ's efficacy and safety.
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