Investigation of In Vitro and In Silico Anti-Inflammatory Potential of Carthamus Caeruleus L. Root Juice
June 2025
in “
International Journal of Molecular Sciences
”
New to Quercetin? There is a guide in the encyclopedia. Read the guide → Studysummary In this study, Carthamus caeruleus root juice exhibited in vitro anti-inflammatory effects by stabilizing human erythrocyte membranes and inhibiting albumin denaturation, as well as showing potential inhibition of COX-2 through in silico analysis; however, further research is needed to confirm efficacy and mechanisms.
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The study explores the anti-inflammatory potential of Carthamus caeruleus L. root juice (CRJ) using in vitro and in silico methods. CRJ demonstrated significant protective effects against various stress-induced damages in erythrocytes, with protection levels up to 90.51%. It also inhibited albumin denaturation by 61.5%. Molecular docking revealed strong interactions between CRJ flavonoids and the COX-2 enzyme, suggesting a mechanism similar to standard anti-inflammatory drugs. Despite promising results, further in vivo studies are necessary to confirm CRJ's efficacy and safety.
